Product Name: Nickel Cycloalkanoate
Chemical Formula: Variable (General format: Ni(O2CR)2, with R as cycloalkyl group)
Synonyms: Nickel(II) cyclohexanecarboxylate, Nickel cyclopentanecarboxylate
CAS Number: Varies by derivative (common range: 64363-34-6 to 69382-47-0)
Manufacturer: Industrial chemical suppliers and research chemical vendors
Recommended Use: Catalyst precursor, intermediate in organic synthesis, academic research
Restrictions: Not intended for drugs, food additives, or household products
Emergency Contact: Local poison center, fire department, or chemical emergency response
GHS Classification: Acute Toxicity (Oral - Category 4), Skin Sensitizer (Category 1), Carcinogenicity (Category 1), Specific Target Organ Toxicity (Category 2), Aquatic Hazard (Acute/Chronic - Category 1)
Signal Word: Danger
Hazard Statements: Harmful if swallowed or inhaled; causes skin irritation; suspected of causing cancer; may cause allergic skin reactions; toxic to aquatic life with long lasting effects
Precautionary Statements: Wear suitable protective clothing and gloves, avoid breathing dust or fumes, wash skin thoroughly after handling, do not eat, drink, or smoke near chemical
Label Elements: Skull and crossbones, exclamation mark, health hazard
Chemical Name: Nickel Cycloalkanoate
Common Components: Nickel ion (20–30%), cycloalkanoic acid residue (balance, 70–80%)
Impurities: Trace solvents or unreacted acid (<1%), no known stabilizers
Purity: Research and industrial grades typically >97% by weight
Inhalation: Move to fresh air, seek medical attention for persistent symptoms, administer oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing, wash skin immediately with large amounts of water and mild soap, consult a physician if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, continue rinsing and call a doctor
Ingestion: Rinse mouth thoroughly, never induce vomiting if victim is unconscious, seek immediate medical attention, provide information on the chemical
Delayed Effects: Allergic reactions, possible late-developing respiratory or renal symptoms
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, use water spray to cool containers
Unsuitable Media: Direct water jet (may spread contamination)
Specific Hazards: Produces hazardous nickel oxide or noxious organic vapors under fire, decomposition may release carbon oxides
Protective Equipment: Full protective gear, self-contained breathing apparatus, chemical-resistant boots and gloves
Special Procedures: Remove containers from fire area if safe, prevent runoff from reaching water systems
Personal Precautions: Use proper personal protective equipment (PPE); avoid inhaling dusts or vapors; ensure adequate ventilation
Environmental Precautions: Prevent material from entering sewers or waterways; contain spillage with sand or inert absorbents
Cleanup Methods: Scoop or sweep solids into sealed containers; dispose following hazardous waste protocols; wash spill area thoroughly
Emergency Procedures: Evacuate unnecessary personnel, notify relevant authorities, limit spread with barriers or dikes
Safe Handling: Work in well-ventilated locations; minimize dust production and airborne particles; avoid contact with eyes, skin, and clothing
Storage Conditions: Store tightly closed in original containers, keep in cool, dry places away from acids and oxidizers
Incompatible Materials: Strong acids, strong oxidizing agents, reducing agents
Technical Measures: Use explosion-proof equipment where dust or vapor may accumulate, employ secondary containment for large volumes
Hygiene Measures: Wash hands thoroughly after use, avoid cross-contamination with other chemicals
Occupational Exposure Limit (Nickel): OSHA PEL: 1 mg/m³ (as Ni), ACGIH TLV: 0.1 mg/m³ (inhalable fraction)
Engineering Controls: Local exhaust ventilation, closed-handling systems, dust collection
Personal Protective Equipment: Chemical resistant gloves (nitrile, neoprene), laboratory coats, safety goggles, particulate respirator (NIOSH N100 or higher)
Environmental Controls: Avoid emissions to environment; use spill trays and vapor filters
Monitoring: Regular air and surface sampling in handling areas
Appearance: Greenish powder or crystalline solid
Odor: Mild chemical or fatty odor
pH (1% solution): 6–8
Melting Point: 210–320°C (may depend on specific cycloalkanoate group)
Boiling Point: Decomposes before boiling
Vapor Pressure: Negligible at 25°C
Solubility: Slightly soluble in water, better solubility in organic solvents (alcohols, ketones)
Density: 1.7–2.4 g/cm³
Partition Coefficient (log Kow): Expected moderate (data varies by derivative)
Flammability: Not classified as readily flammable, though organic ligand may support combustion
Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Moisture, elevated heat, open flames, sources of ignition
Incompatible Materials: Strong acids, strong oxidizers, reducing metals
Hazardous Decomposition: Nickel oxides, carbon dioxide, carbon monoxide, possible traces of organics
Polymerization: Does not undergo hazardous polymerization
Sensitivity: Not impact sensitive, but dust can form explosive mixes with air
Acute Toxicity: Ingestion or inhalation may cause nausea, dizziness, lung irritation, metallic taste, abdominal cramps
Skin Exposure: May cause sensitization, rashes, chronic dermatitis; nickel compounds linked to allergic reactions
Chronic Toxicity: Prolonged exposure linked to asthma-like symptoms, increased cancer risk (respiratory tract), kidney damage
Carcinogenic Classification: IARC Group 1 (carcinogenic to humans – inhalation of certain nickel compounds)
Mutagenicity/Reproductive Effects: Evidence for mutagenic and reproductive toxicity in animal studies
Organ System Effects: Respiratory, dermal, renal, potential cardiovascular in nickel-sensitive individuals
Environmental Toxicity: Highly toxic to aquatic organisms (nickel, organic acid component)
Persistence: Low biodegradability, long-term persistence in aquatic environments
Bioaccumulation: Tendency for nickel to accumulate in aquatic food chains; risk to fish and invertebrates
Mobility: Low solubility in water, may bind to sediments or soil organic matter
Other Hazards: Release may harm local ecosystem structure, disrupt microorganism balance, threaten plant health
Residue Disposal: Treat as hazardous waste; incinerate in approved facility or landfill following local, state, and federal laws
Container Disposal: Triple rinse, puncture, and dispose according to hazardous waste protocol
Sewage Disposal: Prohibited due to environmental toxicity
Precautionary Practices: Segregate from general waste streams, use designated disposal contractors, track waste movement to final fate
UN Number: UN 3288 (Toxic Solid, Inorganic, N.O.S.)
Proper Shipping Name: Toxic solid, inorganic, n.o.s. (contains nickel compound)
Transport Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Hazard Label: Toxic
Special Provisions: Keep apart from food and feedstuffs, protect from moisture during transit, emergency response guide required
Additional Info: Regulated for air, road, rail, and sea; common exemptions do not apply for laboratory scale due to carcinogenic risk
OSHA: Regulated under Hazard Communication Standard, nickel classified as a carcinogen
EPA: Reportable as a hazardous substance under CERCLA and SARA Title III (Section 313, community right-to-know)
EU REACH: Restrictions apply, subject to authorization, classified under CLP as a category 1 carcinogen
Canada WHMIS: Classified D2A, very toxic material causing other toxic effects
California Proposition 65: Listed as a chemical known to cause cancer
International: Transport and environmental controls enforced in many jurisdictions (UN GHS system)
Labeling:-Comply with national and international labeling, provide SDS in workplace for all users
User Obligation: Inform workers, train staff, implement control measures to reduce exposures
